Lung cancer
Lung cancer is the 3rd most common cancer in the UK with over 48,000 new cases each year. It is also the cancer with the highest mortality rate in the UK accounting for 21% of all cancer deaths.
Survival is closely linked to the stage at diagnosis with 57% 5-year survival for Stage 1 cancers dropping to 3% 5 year survival for Stage 4 cancers. Many lung cancers are advanced at diagnosis with over 34,000 lung cancer deaths annually in the UK.
Increasing age and tobacco exposure remain the most important risk factors for lung cancer. However, 10-25% of lung cancers occur in never smokers.
There is a strong correlation between deprivation and lung cancer. In England, lung cancer incidence rates in females are 174% higher in the most deprived quintile compared with the least, and 168% higher in males.
Symptoms
Early symptoms of lung cancer can mimic common illnesses making diagnosis difficult especially during the Covid pandemic:
- cough
- fatigue
- shortness of breath
- chest pain
- weight loss
- appetite loss
The unexplained presence of two of these symptoms in never-smokers aged 40 or older, or just one of these symptoms in people who have ever smoked aged 40 or older should prompt an urgent chest X-ray. As should any of the following signs in anyone over 40:
- persistent or recurrent chest infection
- finger clubbing
- supraclavicular lymphadenopathy or persistent cervical lymphadenopathy
- chest signs consistent with lung cancer
- thrombocytosis
Clearly if a patient under 40 years of age has suspicious symptoms they also need investigating, the NICE guidelines are exactly that - a guide.
However, chest X-rays miss 25% of lung cancers making it important for neither GP nor patient to be reassured by a negative chest X-ray in the presence of ongoing symptoms. In this instance a 2 week wait fast track referral should be completed using the “Normal chest x-ray but clinical suspicion” tick box.
Unexplained haemoptysis in a patient aged 40 or older should also prompt a lung cancer 2 week wait fast track referral, as these patients require a CT scan (an X-ray is not mandatory prior to referral and should not slow down a referral, however it may help acute trusts triage the referrals and arrange the most appropriate CT scan).
The treatment for lung cancer depends on the stage at diagnosis. At stage one, treatment can be curative. However, as mentioned earlier patients often present with late stage disease. Targeted lung health checks (see below) are being rolled out across the UK to try and tackle this issue.
Lung cancer statistics | Cancer Research UK
Lung cancer | Cancer Research UK
Suspected cancer: recognition and referral | NICE Guideline [NG12]
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