HIV (human immunodeficiency virus) attacks the body’s immune system and, if not treated, can lead to AIDS (acquired immunodeficiency syndrome).
Because of medical advancements, including antiretroviral therapy (ART), many people now live long lives with HIV, but researchers believe long-term viral control in the absence of ART (i.e. remission) might be possible.
In pursuit of an HIV remission, researchers at the Emory National Primate Research Center (EPC) are working to lower HIV persistence. They recently discovered the anti-inflammatory protein, interleukin-10, may be responsible for helping sustain cellular reservoirs, which enable the virus to hide. This breakthrough may lead to treatments that can block the effects of interleukin-10 and, therefore, reduce viral persistence, which is critical to finding alternative therapies to control HIV.