We are exposed to many different man-made chemical compounds every day, with exposure to new toxicants being much higher than what our ancestors experienced. There are several common GST variants that decrease the function of the GST enzymes. (Member's only article). ​

HMGB1 is a protein with many important roles, like the well known Swiss Army knife. Its role is dependent on its location in the body and its range runs from nuclear protein to inflammatory alarmin. A SARS-CoV-2 interaction exists and HMGB1 seems to play an integral role in the severe SARS-CoV-2 response by some people.

Genetic variants in our odor receptors cause us to experience our surroundings in different ways. Some people might find an odor pleasant while others might not be able to detect it at all. This difference can have interesting results from not smelling particular florals to the propensity for a higher BMI.

Several popular drugs such as Prilosec, Nexium, and Plavix are metabolized by the CYP2C19 enzyme. There are important genetic variants in the CYP2C19 gene that changes how fast or slowly these drugs are broken down. Learn how these variants might affect their efficacy. (Member's only article)

This interesting new animal study shows that the IgE antibodies responsible for allergic reactions can be transferred across the placenta to the fetus. The babies then develop allergies at the first exposure to the allergen.

A new animal study looks at the effects of a “novel microdose lithium formulation” called NP03. The study used transgenic rats that were developed to have Alzheimer’s-like pathogenesis from amyloid plaque. The results showed that the microdosed lithium reversed the cognitive deficits in the animal model of Alzheimer's.